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The University of Hong Kong - Queen Mary Hospital Assisted Reproductive Centre Marks 40 Years: Combining Clinical Expertise with Technology to Advance Fertility Care and Bring Hope to Parenthood

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編輯: 編輯部
日期: 2026-11-01

香港大學瑪麗醫院輔助生育中心40週年里程碑與變化:臨床智慧結合科技-現代化孕育生育希望

▲ Professor Ernest Ng Hung Yu, Dr. Jennifer Ko Ka Yi, and Dr. Kevin Lam Ka Wai (Director of the IVF Laboratory)(From Left to Right)

Since its establishment in 1986, the Assisted Reproductive Centre at The University of Hong Kong–Queen Mary Hospital has been at the forefront of reproductive medicine for four decades. Over the years, the Centre has achieved numerous local medical milestones, pioneering advancements such as intracytoplasmic sperm injection (ICSI) and preimplantation genetic diagnosis (PGD), helping countless families realize their dream of parenthood.

As the Centre marks its 40th anniversary, how is the team building on decades of technological advancement and clinical expertise while embracing cutting-edge innovations to continue leading the next chapter of assisted reproductive medicine in Hong Kong?

The University of Hong Kong - Queen Mary Hospital Assisted Reproductive Centre Marks 40 Years: Combining Clinical Expertise with Technology to Advance Fertility Care and Bring Hope to Parenthood_圖_2

▲ The Assisted Reproductive Centre at The University of Hong Kong–Queen Mary Hospital was officially established and began providing clinical services. (Photo courtesy of the interviewee.)

Looking back over the past 40 years, the Assisted Reproductive Centre at The University of Hong Kong–Queen Mary Hospital has achieved numerous significant milestones in the history of assisted reproduction in Hong Kong. Established in 1986, the Centre overcame the challenges of limited resources during its early years. Just two years later, it celebrated the birth of its first IVF baby, marking a breakthrough and bringing new hope to countless families struggling with infertility. The Centre has continued to push the boundaries of reproductive medicine. In 1995, it performed Hong Kong’s first intracytoplasmic sperm injection (ICSI) procedure, marking a major milestone in the development of assisted reproductive technology in the territory. This breakthrough has enabled countless couples affected by severe male-factor infertility to achieve their dream of parenthood, and today, approximately 20% of families seeking treatment at the Centre benefit from this technique.

In addition, the Centre was the first institution in Hong Kong to offer preimplantation genetic testing (PGT), enabling couples carrying hereditary disease-causing genes to avoid the emotional burden of the cycle of conception, prenatal detection of abnormalities, and pregnancy termination. The testing covers both chromosomal abnormalities and single-gene disorders.

Committed to the principles of evidence-based medicine, the Centre has conducted the largest number of randomized clinical trials in Hong Kong, translating the latest scientific research into safe, effective, and clinically proven treatment strategies for patients.

The University of Hong Kong - Queen Mary Hospital Assisted Reproductive Centre Marks 40 Years: Combining Clinical Expertise with Technology to Advance Fertility Care and Bring Hope to Parenthood_圖_3

▲ Celebrating the successful birth of the first baby following preimplantation genetic testing (PGT).

From a Humble Laboratory to a State-of-the-Art Fertility Care Facility

Looking back over the years, the Centre has undergone remarkable transformations in both its facilities and clinical processes. Professor Ernest Ng Hung Yu of the Assisted Reproductive Centre at The University of Hong Kong–Queen Mary Hospital shared:

“In the past, our laboratory was very small (located on the 6th floor). Today, the Centre has fully independent laboratories equipped with a wide range of advanced facilities. As times have changed, so have patients’ needs. I still remember that consultation areas used to be located in an open space in the main lobby. However, recognizing the importance of patient privacy, our consultation areas have now been transformed into dedicated consultation rooms and separate waiting areas.”

Today, the Centre’s multidisciplinary team has also expanded to more than 40 professionals, providing comprehensive and integrated care for patients seeking assisted reproductive treatment.

The University of Hong Kong - Queen Mary Hospital Assisted Reproductive Centre Marks 40 Years: Combining Clinical Expertise with Technology to Advance Fertility Care and Bring Hope to Parenthood_圖_4

▲ Today, the Centre’s multidisciplinary team comprises over 40 professionals

Meanwhile, the overall treatment process has become more streamlined and patient-centred, providing greater convenience for patients.

“In the past, patients undergoing treatment often had to return to the hospital almost every day throughout the treatment cycle for injections, frequent blood tests, and ultrasound monitoring. Following process optimization, the stimulation cycle now takes approximately 11 to 12 days, during which patients only need to visit the hospital for around three follow-up appointments, significantly reducing the inconvenience caused by frequent travel.

In addition, following the COVID-19 pandemic, patients have become more receptive to virtual healthcare solutions. As a result, the hospital has gradually expanded the use of telemedicine services, including online seminars and virtual consultations.”

Advancing Pregnancy Outcomes Through Optimized Ovulation Protocols and Enhanced Patient Comfort.

Since 2016, the Centre has adopted a single embryo transfer strategy. Today, the Centre’s multiple pregnancy rate has been successfully reduced to just 1%–2%, comparable to that of natural conception. This approach not only enhances maternal safety but also provides embryos with a more favourable environment for development within the uterus.

The team noted that while the live birth rate associated with transferring two embryos is not significantly different from the cumulative live birth rate achieved through single embryo transfer, the full-term live birth rate (defined as delivery after 37 weeks of pregnancy) is actually higher with single embryo transfer.

In terms of treatment outcomes, the Centre’s pregnancy rate has increased significantly from 8%–10% in the 1990s to 30%–40% per treatment cycle today, with the cumulative live birth rate reaching approximately 70% at its highest.

In terms of ovarian stimulation protocols, the Centre has transitioned from the traditional long agonist protocol to the antagonist protocol, reducing the number of hospital visits required. At the same time, 80%–90% of patients are now able to administer subcutaneous injections themselves, eliminating the need for daily visits to the hospital for injections and greatly enhancing patient autonomy.

The team revealed that they are currently exploring oral antagonist medications, with the aim of further streamlining the treatment process. This advancement will not only improve convenience for patients but also help alleviate the significant physical and emotional burden they experience throughout their assisted reproductive journey.

香港大學瑪麗醫院輔助生育中心40週年里程碑與變化:臨床智慧結合科技-現代化孕育生育希望

▲ Previous fertility health psychological support seminars and workshops

Guided by the patient-centred philosophy of the Assisted Reproductive Centre at The University of Hong Kong–Queen Mary Hospital, the team recognizes that assisted reproduction is not only about advanced medical technology, but also a challenging journey involving both physical and emotional resilience. Therefore, the Centre has established a comprehensive support network to care for patients throughout their treatment journey.

A dedicated psychological counselling consultant stationed at the Centre provides professional emotional support. The Centre also regularly organizes both online and in-person programmes covering areas such as nutritional guidance, exercise recommendations, and sleep management. Through a holistic approach to care, the Centre strives to safeguard the physical, emotional, and psychological well-being of every couple seeking treatment.

To provide early support, patients undergo an initial psychological assessment and screening immediately upon submission of their referral letter, rather than waiting until their first clinical appointment. In terms of patient education, the Centre shares fertility-related information and resources through various platforms, including Facebook, YouTube, and educational seminars, helping patients gain a better understanding of assisted reproductive care.

香港大學瑪麗醫院輔助生育中心40週年里程碑與變化:臨床智慧結合科技-現代化孕育生育希望

▲ Monitoring and assessing fertilization status

Integrating cutting-edge technologies into clinical care

The Centre is currently exploring the application of artificial intelligence (AI) across three key areas:

Using AI models to assist in evaluating sperm quality, overcoming the subjectivity and limitations of traditional visual assessment, and enabling more objective prediction of fertilization success rates.

AI-assisted embryo evaluation:

The Centre is exploring the use of AI-based embryo image analysis. By processing large datasets and leveraging machine-learning capabilities, AI has the potential to enhance embryo assessment. The model is currently being continuously trained and will serve as a supportive tool to assist clinical decision-making.

AI-assisted endometrial assessment

Through whole-slide imaging and AI-powered analysis of endometrial tissue samples, the Centre aims to evaluate endometrial characteristics on a larger scale. Prospective data collection is currently underway to identify key indicators that may contribute to optimizing the uterine environment for successful implantation and pregnancy.

Behind technology and accumulated clinical expertise lies a profound commitment to compassionate care. In the next article, real patient stories will be shared, offering a closer look at how professionals across different roles — including embryologists — work closely together to quietly safeguard the hopes of countless families seeking to build their future.

Join us as we unveil the team’s new vision and blueprint for embracing future opportunities and challenges in assisted reproductive medicine.

 

This article is sponsored by Organon Hong Kong Ltd.

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